mRgnMargination is derived from the second moment of inertia of a region's pixels (those under or interior to its boundary, excluding any Holes). This moment is the distribution of its intensity toward the edges from the center of the object. A high margination indicates that most of the intensity is along the object edges (a donut or ring shape), while a low margination indicates that most of the intensity is near the geometric center of the object (more of a 'gaussian' shape, with thin edges). A margination of 0.333 (1/3) indicates that the object is uniform in intensity distribution.
Note that margination uses calibrated intensities for this calculation.
The measurement was originally described by
Young IT, Verbeek PW, and Mayall BH, Characterization of chromatin distribution in cell nuclei. Cytometry, 1986. 7: p. 467-474.